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A brief focus on memory cells in transplantation.

par Le Moine, Alain ;Vokaer, Benoît ;Charbonnier, Louis-Marie
Référence Transplantation proceedings, 41, 8, page (3361-3362)
Publication Publié, 2009-10

Article révisé par les pairs

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Résumé :

T and B memory cells are critical for host defences against pathogens. However, converging lines of evidence indicate that alloreactive memory T cells can play a detrimental role in the transplantation setting. This emergence of memory cells seems to be facilitated by several induction therapies and immunosuppressive agents, which lead to T cell loss. Herein, we briefly review some clinical and experimental observations from the literature, highlighting the immunological risk associated with enhanced T-cell memory responses.