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Tuberculosis contacts but not patients have higher gamma interferon responses to ESAT-6 than do community controls in The Gambia.

par Vekemans, J;Lienhardt, Christian;Sillah, Jackson;Wheeler, J G;Lahai, G P;Doherty, Margaret;Corrah, T;Andersen, P;McAdam, K P;Marchant, Arnaud
Référence Infection and immunity, 69, 10, page (6554-6557)
Publication Publié, 2001-10

Article révisé par les pairs

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Résumé :

The Mycobacterium tuberculosis antigen ESAT-6 has been proposed for tuberculosis immunodiagnosis. In The Gambia, 30% of community controls produced gamma interferon (IFN-gamma) in response to ESAT-6. Increased proportions of responders and intensities of responses were found in household contacts. Responses that were initially low in tuberculosis patients increased after treatment. An ESAT-6 IFN-gamma assay will be of limited use in the diagnosis of tuberculosis in countries where tuberculosis is endemic. Its role in contact tracing should be evaluated further.