Titre:
  • Genetic immunization of outbred mice with thyrotropin receptor cDNA provides a model of Graves' disease.
Auteur:Costagliola, Sabine; Many, Marie-Christine; Denef, Jean François; Pohlenz, Joachim; Refetoff, Samuel; Vassart, Gilbert
Informations sur la publication:The Journal of clinical investigation, 105, 6, page (803-811)
Statut de publication:Publié, 2000-03
Sujet CREF:Sciences bio-médicales et agricoles
MeSH keywords:Animals
Autoantibodies -- biosynthesis
Autoimmune Diseases -- etiology
Autoimmune Diseases -- immunology
CHO Cells
Cricetinae
Cricetulus
DNA, Complementary -- adverse effects
Disease Models, Animal
Edema -- pathology
Female
Glycosaminoglycans -- analysis
Graves Disease -- etiology
Graves Disease -- immunology
Graves Disease -- pathology
Humans
Immunization -- adverse effects
Immunoglobulins, Thyroid-Stimulating -- biosynthesis
Male
Mice
Oculomotor Muscles -- pathology
Receptors, Thyrotropin -- biosynthesis
Receptors, Thyrotropin -- immunology
Th2 Cells -- immunology
Thyrotropin -- blood
Thyroxine -- blood
Vaccines, DNA -- adverse effects
Note générale:Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.
Langue:Anglais
Identificateurs:urn:issn:0021-9738
info:doi/10.1172/JCI7665
info:scp/0034027425
info:pmid/10727449
PMC377458