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New approach for the preparation of efficient DNA cleaving agents: ditopic copper-platinum complexes based on 3-Clip-Phen and cisplatin.

par Hoog, Paul de;Boldron, Christophe;Gamez, Patrick;Sliedregt-Bol, Karen;Roland, Isabelle ;Pitié, Marguerite;Kiss, Robert ;Meunier, Bernard;Reedijk, Jan
Référence Journal of medicinal chemistry, 50, 13, page (3148-3152)
Publication Publié, 2007-06

Article révisé par les pairs

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Résumé :

The design and synthesis of new heterodinuclear DNA-targeting agents are described. The abilities of cisplatin and Cu(3-Clip-Phen) [Cu(1-(1,10-phenanthrolin-3-yloxy)-3-(1,10-phenanthrolin-8-yloxy)propan-2-amine)Cl2], an artificial DNA-cleaving agent, have been combined through their "covalent coupling". This strategy has led to bifunctional complexes that are able to cleave the DNA in a double-stranded fashion in contrast to Cu(3-Clip-Phen) alone and have promising cytotoxicities compared to cisplatin in several cell lines.