par Cotton, Frédéric 
;Thiry, P;Hsaïn, A B;Boeynaems, Jean-Marie
Référence Clinical laboratory, 47, 7-8, page (405-409)
Publication Publié, 2001
;Thiry, P;Hsaïn, A B;Boeynaems, Jean-Marie Référence Clinical laboratory, 47, 7-8, page (405-409)
Publication Publié, 2001
Article révisé par les pairs
| Résumé : | C-reactive protein (CRP) is measured in two main clinical situations: inflammation, where levels in the range of 5-300 mg/L are expected, and, more recently, assessment of the cardiovascular risk, where concentrations between 0.1 and 10 mg/L shoud be determined. Few commercially available methods display a measuring range covering both zones and laboratories are compelled to use two different assay protocols or even two different methods. The aim of the study was to adapt the Roche C-Reactive Protein (Latex) kit, initially developed for the Roche Cobas Integra analyzers, to the Hitachi Modular P800 analyzer in order to obtain on this instrument a broad range assay for CRP measurement. The method was successfully adapted and validated against a high-sensitivity and a traditional assay. The resulting method correlates well with the other two and displays a measuring range of 0.10-171 mg/L with an imprecision lower than 5.5%. This assay could be particularly practical in the routine clinical laboratory, being suitable for every use of CRP measurements. |
