Cholera and pertussis toxins amplify prostacyclin synthesis in aortic smooth muscle cells

Demolle, Dominique; Boeynaems, Jean-Marie

doi:doi/10.1111/j.1476-5381.1989.tb14597.x

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Cholera and pertussis toxins amplify prostacyclin synthesis in aortic smooth muscle cells

par Demolle, Dominique ;Boeynaems, Jean-Marie

Référence British Journal of Pharmacology, 98, 3, page (717-720)
Publication Publié, 1989-11

Article révisé par les pairs

Résumé :

Pretreatment of bovine aortic smooth muscle cells in culture with pertussis toxin (PT) or cholera toxin (CT) potentiated the synthesis of prostacyclin (PGI2) induced by 5-hydroxytryptamine (5-HT) and phorbol-12-myristate, 13-acetate (PMA). The production of PGI2 by explants from the bovine aortic media was also synergistically stimulated by 5-HT and CT, whereas PT was inactive. These data are consistent with the hypothesis that guanosine 5'-triphosphate binding proteins are directly involved in the control of phospholipases which release free arachidonic acid for prostaglandin synthesis.

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