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Release of prostacyclin from the dog saphenous vein by 5-hydroxytryptamine.

par Kokkas, B;Boeynaems, Jean-Marie
Référence European journal of pharmacology, 147, 3, page (473-476)
Publication Publié, 1988-03

Article révisé par les pairs

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Résumé :

5-Hydroxytryptamine (5-HT) stimulated the release of prostacyclin (PGI2) from strips of the dog saphenous vein. This stimulation was maintained after mechanical removal of the endothelium. The effect of 5-HT was mimicked by alpha-methyl-5-hydroxytryptamine (alpha-CH3-5-HT) but not by 5-carboxamidotryptamine (5-CT) and it was inhibited by ritanserin. It is concluded that, in the dog saphenous vein, the stimulation of PGI2 release by 5-HT involves 5-HT2 receptors distinct from the '5-HT1-like' receptors that mediate contraction of the vessel.