Résumé : Supplementary cementitious materials (SCM) are commonly used as cement substitution in concrete materials for technical, economical or environmental benefits. The impact of such concrete mixes on the concrete setting, strength, elastic modulus or heat release has been at the centre of the attention for the last decade. However, there exist few comprehensive studies assessing the effect of these combined SCM on the early age deformation potential of concrete. In particular, the prediction of the autogenous deformation of such mixes remains of major interest as there lacks simple models that can be applied to SCM-based concrete. The autogenous deformation is the chemo-mechanical consequences of hydration, including mechanisms such as self-desiccation, swelling, and volumetric changes induced by temperature variations. In this paper, a new methodology in order to decouple the swelling deformation from the self-desiccation deformation is presented. This methodology is applied to various concrete composition containing various amounts and nature of SCM. The swelling deformation is linked to the microstructure development. A new unified model is presented, taking into consideration both the swelling and self-desiccation deformation. This model can be applied to all tested concrete compositions.