par Lonys, Laurent
Président du jury Kinnaert, Michel
Promoteur Nonclercq, Antoine
Co-Promoteur Mathys, Pierre
Publication Non publié, 2016-08-19
Thèse de doctorat
Résumé : In recent years, obesity has literally reached epidemic proportions throughout the world. Gastric electrical stimulation is a recent technique that uses an implanted device to stimulate the stomach and produce a feeling of satiety for overweight and obese patients. However, to place the implant, the patient currently needs to undergo an invasive surgical procedure. Endoscopic implantation could be used to place the gastric stimulator in the stomach. This would help moderately and morbidly obese patients that are ineligible for surgery, but such a solution brings new challenges for the development of the gastrostimulator. This thesis is a first step toward a commercial implant, endoscopically implantable and treating obesity. This work mainly focuses on the design and implementation of a first endoscopically implantable prototype, to be validated on animals. This will allow us to prove the feasibility of the project, through a pre-clinical phase on animals. Compared to previous devices, the prototype developed is specifically designed to stimulate the stomach using embedded electrodes. Its design allows endoscopic implantation. Its packaging resists long-term implantation in an acidic environment, hence overcoming the shortcomings of previous gastrostimulators. A flexible and low-cost manufacturing chain is implemented. The prototype is built with discrete components, commercially available, and encapsulated with silicone rubber. This thesis also provides a method to select a silicone rubber for the encapsulation of an electronics circuit. The validation of the prototype is performed on a bench-test, in ex-vivo and in-vivo on three dogs. A new method using surface cutaneous electrodes is introduced to validate the functioning of the stimulator.

Documents en relation

DI-fusion