par Lemaitre, Alex 
;Van Reck, Jack Walter
Référence Acta Stomatologica Belgica, 73, 3, page (279-285)
Publication Publié, 1976
;Van Reck, Jack Walter Référence Acta Stomatologica Belgica, 73, 3, page (279-285)
Publication Publié, 1976
Article révisé par les pairs
| Résumé : | Whilst the Crouzon's disease is transmitted in a dominant way, by a dominant autosomic gene, at variable expression and penetration, it is doubtful whether the Apert Crouzon's disease should be considered genetic. Although elements of the clinical aspect (such as craniostenosis, exophthalmos, mandibular pseudoprognathism, etc.) are common to both syndromes, it can be asserted with a good margin of safety that only the first syndrome has a well defined genetic basis; the Apert Crouzon syndrome seems to be due to spontaneous mutation. Future research must concentrate on 2 important elements, that is: very careful investigation of the family; and anthropometric measurements that allow one to identify those cases which have a vague symptomatology and can thus pass unnoticed when clinical examinations are insufficient. |
