par Brossard, Philippe;Barlow, Patricia 
; [et al.]
Référence AIDS, 22, 15, page (2013-2017)
Publication Publié, 2008
; [et al.]Référence AIDS, 22, 15, page (2013-2017)
Publication Publié, 2008
Article révisé par les pairs
| Résumé : | Objective: To assess the impact of HIV infection on the reliability of the first-trimester screening for Down syndrome, using free β-human chorionic gonadotroph in, pregnancy-associated plasma protein-A and fetal nuchal translucency, and of the second-trimester screening for neural tube defects, using α-fetoprotein. Patients and methods: Multicentre study comparing the multiples of the median of markers for Down syndrome and neural tube defect screening among 214 HIV-infected pregnant women and 856 HIV-negative controls undergoing a first-trimester Down syndrome screening test, and 209 HIV-positive women and 836 HIV-negative controls with a risk evaluation for neural tube defect. The influence of treatment, chronic hepatitis and HIV disease characteristics were also evaluated. Results: Multiples of the median medians for pregnancy-associated plasma protein-A and β-human chorionic gonadotrophin were lower in HIV-positive women than controls (0.88 vs. 1.05 and 0.84 vs. 1.09, respectively; P< 0.005), but these differences had no impact on risk estimation; no differences were observed for the other markers. No association was found between HIV disease characteristics, antiretroviral treatment use at the time of screening or chronic hepatitis and marker levels. Conclusion: Screening for Down syndrome during the first trimester and for neural tube defect during the second trimester is accurate for HIV-infected women and should be offered, similar to HIV-negative women. © 2008 Wolters Kluwer Health |
