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Long-term results of low-fluence photodynamic therapy for chronic central serous chorioretinopathy

par Leys, E;Tuttle, S.;Rasquin, Florence ;Neu, F.;Postelmans, Laurence
Référence Journal français d'ophtalmologie, 38, 8, page (709-716)
Publication Publié, 2015-10

Article révisé par les pairs

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Résumé :

To evaluate long-term results of low-fluence photodynamic therapy (PDT) with verteporfin in the treatment of chronic central serous chorioretinopathy (CCSC). Methods.-Retrospective medical record review of 38 eyes (34 patients) who received lowfluence PDT for the treatment of CCSC. Visual acuity (VA), fundus biomicroscopy, fluorescein angiography (FA), indocyanine green angiography (ICG) and optical coherence tomography (OCT) were analyzed. Results.-Thirty-eight eyes (34 patients) with CCSC received low-fluence PDT. Mean follow-up after PDT was 43.97 months. Mean logMar best corrected VA (BCVA) improved significantly from 0.33 to 0.11 at the last follow-up which corresponds to a gain of 2.2 lines. At 3 months, complete resolution of central subretinal fluid was achieved on OCT after 1 PDT in 37 eyes and after 2 PDTs in 1 eye (retreated at 3 months after first PDT). One patient developed choroidal neovascularization (CNV) 4 years after his low-fluence PDT and received anti-vascular endothelial growth factor (VEGF) injections. Conclusion.-Low-fluence PDT with verteporfin for CCSC seems efficacious and safe in thelong-term.