par Libert, Frédérick 
;Vassart, Gilbert ;Christophe, Daniel
Référence Biochemical and biophysical research communications, 134, 3, page (1109-1113)
Publication Publié, 1986
;Vassart, Gilbert ;Christophe, Daniel Référence Biochemical and biophysical research communications, 134, 3, page (1109-1113)
Publication Publié, 1986
Article révisé par les pairs
| Résumé : | The DNA methylation pattern at the 5'end of the human thyroglobulin gene has been determined in different tissues. Out of the four HpaII/MspI sites (5'-CCGG-3') present in this region, three were found to be non-methylated in thyroid DNA, while full methylation was observed in liver, salivary gland and sperm DNA. This demethylation therefore correlates with expression of the thyroglobulin gene. However, all four sites were found to be non-methylated in placental DNA, regardless of the activity of the gene. |
