par Malaisse, Willy ;Moratinos, Julio
Référence IRCS Medical Science, 14, 12, page (1194-1195)
Publication Publié, 1986
Article révisé par les pairs
Résumé : The selective α1-adrenergic agonist amidephrine mesylate, when used at concentrations ranging from 0.01 to 100 μM, failed to significantly affect insulin release by isolated rat pancreatic islets incubated for 90 min at either a close-to-physiological (7.0 mM) or higher (16.7 mM) D-glucose concentration. When the islets were prelabelled with myo-[2-3H(N)]inositol and then perifused in the presence of 11.1 mM D-glucose, the administration of amidephrine mesylate (1.0 μM) also failed to cause any obvious change in either the rate of insulin secretion or outflow of tritiated inositol. These findings suggest that, at least in adult rats, the pancreatic B-cell is virtually devoid of α1-adrenoceptors. Direct investigation on the binding of α1-adrenergic agonists and/or antagonists to purified B-cells would seem desirable to assess the validity of such a tentative conclusion.