par Beumier, Marjorie ;Casu, Giuseppe Stefano;Hites, Maya ;Wolff, Fleur ;Cotton, Frédéric ;Vincent, Jean Louis ;Jacobs, Frédérique ;Taccone, Fabio
Référence Minerva anestesiologica, 81, 5, page (497-506)
Publication Publié, 2015-05
Référence Minerva anestesiologica, 81, 5, page (497-506)
Publication Publié, 2015-05
Article révisé par les pairs
Résumé : | Background. Although β-lactams are considered to have a safe therapeutic profile, neurotoxicity has been reported. The aim of this study was to assess the association between β-lactam concentrations and neurological alterations in septic ICU patients. Methods. Retrospective study on all ICU patients who were treated with meropenem (MEM), piperacillin-tazobactam (TZP) or ceftazidime/cefepime (CEF) and in whom at least one β-lactam trough concentration (C |