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One-year follow-up of vaccine therapy in hiv-infected immune-deficient individuals: A new strategy

par Zagury, Daniel;Zagury, Jean-François;Salaun, Jean Jacques;Lurhuma, Zirimwabagangabo;Mbayo, Kalumbu;Aboud-Pirak, Esther;Lowell, George;Lebon, Pierre;Burny, Arsène ;Picard, Odile;Bernard, Jacky;Halbreich, Avraham;Bizzini, Bernard;Carelli, Claude;Achour, Ammar;Defer, Marie Christine;Bertho, Jean Marc;Lanneval, K.
Référence Journal of acquired immune deficiency syndromes, 5, 7, page (676-681)
Publication Publié, 1992

Article révisé par les pairs

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Résumé :

Immunization of AIDS/ARC patients with autologous cells expressing HIV antigens, although providing clinical and biological benefits, fails to restore cellular immunity. The latter result is due partly to the antiproliferative effect of HIV-1 on activated T-cells (immune suppression), which leads to blockade of specific immune reactions. To overcome immune suppression, a new vaccine strategy was designed consisting of an immunization against HIV-1 combined with components of the T-cell-suppressive (antiproliferative) network. This new vaccine treatment proved to be innocuous in mice, monkeys, and two non-HIV-infected humans. A Phase I clinical trial was performed in six patients previously under cellular immunotherapy and still presenting a cellular immune defect. Preliminary results confirmed, after a 1-year follow-up of the patients, the safety of the new vaccine, which also partially restored the cellular immune response, including anti-HIV HLA-restricted cell-mediated cytotoxicity, delayed hypersensitivity to recall antigens, and proliferation of T-cells specifically activated by recall antigens. © 1992 Raven Press, New York.