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Determination of the anticancer drug sorafenib in serum by adsorptive stripping differential pulse voltammetry using a chitosan/multiwall carbon nanotube modified glassy carbon electrode

par Karadas-Bakirhan, Nurgul;Patris, Stéphanie ;Ozkan, Sibel;Can, Alp;Kauffmann, Jean-Michel
Référence Electroanalysis, 28, 2, page (358–365), 10.1002/elan.201500384
Publication Publié, 2016-02-01

Article révisé par les pairs

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Résumé :

Adsorptive stripping differential pulse voltammetry (AdSDPV) was applied to the assay of sorafenib in human serum sample. Cyclic voltammetry at a carbon based screen printed electrode (SPE) permitted to detect the irreversible oxidation of SOR with formation of a new compound reversibly oxidized at a lower potential. Quantitative assays were realized using a chitosan/carboxylic acid functionalized multiwalled carbon nanotube modified glassy carbon electrode in 0.1M phosphate buffer pH7.0 in the presence of 50% methanol. The AdSDPV method provided two linear responses within the concentration ranges 1×10-8-8×10-8M and 1×10-7-8×10-7M in serum with LOQ and LOD of 3.2×10-9 and 9.6×10-10 of lower linear range, respectively. The recovery of sorafenib in spiked serum was 97.5%.