• Citer

Effets de l'acétate de cortisone sur la sécrétion acide provoquée par l'histamine, la pentagastrine, la gastrine et le repas chez le chien

par Brihaye, Claude ;Chavez Garcia, Edison ;Woussen Colle, Marie-Claire ;Limbosch, Jean-Michel
Référence Archives of physiology and biochemistry, 84, 1, page (105-113)
Publication Publié, 1976

Article révisé par les pairs

• Détails
• Contenu

Résumé :

The effects of long term treatment with cortisone on the gastric secretion induced by histamine, pentagastrin, porcine gastrin and a meal have been investigated in four dogs with both gastric fistula and Heidenhain pouch. Cortisone increased the postcibal acid output and the observed maximal acid response from the pouch to all three exogenous stimuli. The ED 50′s remained unchanged. The same effects although less marked were observed in the innervated stomach. These data indicate that the increased acid secretion observed after long term treatment with cortisone is largely due to an increased secretory capacity of the gastric mucosa. This latter could result from an increase in the number of secretory units or to partial removal of a non competitive inhibitor of gastric secretion. Ce travail a été réalisé avec l'aide du subside nd̀' 20.318 du Fonds de la Recherche Scientifique Médicate (Belgique). Les auteurs remercient Mr. L. Asselberghs pour l'aide technique apportée au cours de la réalisation de ce travail. © 1976 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.