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Enhanced in vitro release of indomethacin from non-aqueous suspensions using indomethacin-polyvinylpyrrolidone coprecipitate

par Oth, Marianne P. ;Moes, André Jules
Référence International journal of pharmaceutics, 24, 2-3, page (275-286)
Publication Publié, 1985

Article révisé par les pairs

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Résumé :

The release of indomethacin and indomethacin-polyvinylpyrrolidone (PVP) coprecipitate (1:1) from non-aqueous suspensions to aqueous phase has been investigated. The coprecipitation with polyvinylpyrrolidone increases the solubility and the intrinsic dissolution rate of the drug. The release rate from non-aqueous suspension is significantly enhanced when the coprecipitate form is used and that at any pH and concentrations. The use of indomethacin-PVP coprecipitate avoids the formation of a cake at the oil/water interface due to an increase of the solubility and wetting of the drug included in the coprecipitate. The partition coefficient of indomethacin is not significantly reduced by the presence of PVP in the medium. The dialysis studies show that indomethacin is only weakly bound to PVP and therefore, PVP might only interfere weakly in the resorption process of the free drug through the biological membrane. © 1985.