par Sobolski, John;Westelinck, KJ;Abramowicz, Michel
Référence Current therapeutic research, 41, 1, page (30-37)
Publication Publié, 1987
Article révisé par les pairs
Résumé : The effects of a single oral dose of 4-mg bopindolol were studied in eight patients in a single-blind placebo-controlled study. Continuous electrocardiogram recordings made over 72 hours after drug administration showed that bopindolol had no effect on minimal heart rate, but reduced maximal heart rate significantly (P < 0.005) for at least 48 hours after treatment. During exercise to 60 watts, bopindolol significantly reduced exercise-induced tachycardia for up to at least 72 hours posttreatment (P < 0.05). At this mild level of exercise in patients with stable angina pectoris no statistically significant effect on systolic and diastolic blood pressure was demonstrated. We conclude that bopindolol is a long-acting beta-receptor antagonist with moderate intrinsic sympathomimetic activity.