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RESULTATS ET APPLICATIONS POSSIBLES DE LA MICROBIOPSIE DE L'OEUF: DETERMINATION DU SEX ET ANOMALIES GENIQUES

par Liebaers, Ingeborg ;Lissens, Willy;Liu, Jiaen;Sermon, Karen;Devroey, Paul;Van Steirteghem, André
Référence Contraception Fertilite Sexualite, 20, 9, page (892-895)
Publication Publié, 1992

Article révisé par les pairs

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Résumé :

Clinicians and scientists as well as couples at risk for genetic diseases have asked the question whether it is possible to select before fertilization or intra-uterine replacement oocytes and embryos that do not have a particular disease. Several researchers have demonstrated that the removal of polar bodies from an oocyte or the biopsy of one of two blastomeres from an embryo has no detrimental effect on further development. Furthermore several microprocedures have been developed for gender determination and for the detection of chromosomal, biochemical and genetic abnormalities on single cells. So far, the clinical application of these methods is still limited. Further research is needed to determine whether preimplantation diagnosis may have a similar application in prenatal diagnosis as amniocentesis and chorionic villous sampling. The current research provides some basic information such as the variability in gene expression among the different species.