par Kahn, André 
;Brachet, Etienne
Référence Pathologie et biologie, 28, 7, page (449-451)
Publication Publié, 1980
;Brachet, Etienne Référence Pathologie et biologie, 28, 7, page (449-451)
Publication Publié, 1980
Article révisé par les pairs
| Résumé : | There is no uniform agreement about the effects of bacterial endotoxins upon vascular permeability. We report here some clinical observations indicating an increase in vascular permeability during septicemia and shock related to Neisseria meningitidis in children. 133 children, admitted for a severe infection due to Neisseria m., were separated into 3 groups according to the severity of the initial clinical picture. The patients presenting with septicemia or shock had significantly lower mean plasma protein levels on admission; but this was not related to any hemodilution or protein deficiency able to explain the phenomenon. Hypo-proteinemia worsened during the first 24 hours of treatment, despite hemoconcentration as presented by some patients (12), indicating a protein leakage to the extravascular spaces. The speed of decrease in protein concentrations was inversely related to the molecular weights of the different protein fractions. These observations indicate an increase in vascular permeability with maintenance of vascular membrane selectivity to macromolecules during early meningococcic septicemia and shock. |
