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Growth curve patterns of Escherichia coli submitted to cefaclor and cephalexin

par Yourassowsky, Eugène ;Van der Linden, Martial;Lismont, M.J.
Référence Current therapeutic research, 37, 6, page (1160-1166)
Publication Publié, 1985

Article révisé par les pairs

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Résumé :

The chemical instability of cefaclor handicaps the in-vitro evaluation of its antimicrobial effect when compared to cephalexin. The continuous turbidimetric study of 8 Escherichia coli cultures subjected to cephalexin and cefaclor showed that the minimum inhibitory concentrations (MIC) of the antibiotics, after 20 hours of incubation, were similar (14 μg/ml). Lysis occurred at 16 μg/ml for cefaclor and at 250 μg/ml for cephalexin. The MIC measured after 8 hours of incubation was 2 μg/ml for cefaclor as opposed to 6 μg/ml for cephalexin. The minimum antibiotic concentration (MAC), estimated by the divergence of the growth curve in relation to the control curve within the first 8 hours of antibiotic-culture contact, was 1/3 of the MIC for cephalexin and 1/40 for cefaclor. In conclusion, continuous turbidimetric study of cultures of Escherichia coli showed that cefaclor has an antimicrobial effect at lower concentrations than cephalexin.