• Citer

Activity of cefsulodin against methicillin-resistant Staphylococcus aureus

par Glupczynski, Youri;Crokaert, Françoise ;Van der Linden, Martial;Yourassowsky, Eugène
Référence Current therapeutic research, 37, 3, page (467-471)
Publication Publié, 1985

Article révisé par les pairs

• Détails
• Contenu

Résumé :

Despite the fact that cefsulodin has been considered essentially as an antipseudomonal antibiotic, a good activity was demonstrated against β-lactamase-positive Staphylococcus aureus. The minimal inhibitory concentration (MIC) of cefsulodin against methicillin-resistant Staphylococcus aureus (50 strains) was determined by an agar-dilution method. The median MIC value was 6.25 μg/ml. The minimal bactericidal value (MBC) never exceeded 12.5 μg/ml. The growth curves obtained with the MS-2 system showed that regrowth did not occur at cefsulodin concentrations MIC x 2, x 4, x 8. No regrowth was observed after 24 hours. The lag of regrowth in the post-antibiotic period (β-lactamase technique) at cefsulodin concentrations MIC x 2, x 4, x 8 was identical to those observed with penicillin G against a Staphylococcus aureus not producing β-lactamase. These in-vitro data should encourage a clinical trial in order to assess the in-vivo efficacy of cefsulodin against staphylococcal infections.