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Substitution between Aristolochia and Bryonia genus in North-Eastern Morocco: toxicological implications.

par Yamani, Amal;Bunel, Valérian ;Antoine, Marie-Hélène ;Husson, Cécile ;Stévigny, Caroline ;Duez, Pierre ;Elachouri, Mostafa;Nortier, Joëlle
Référence Journal of ethnopharmacology, 166, page (250-260)
Publication Publié, 2015-05

Article révisé par les pairs

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Résumé :

Although acknowledged as toxic herbs, Aristolochia species are still widely used worldwide. The aristolochic acids (AA) they contain can induce the so-called "aristolochic acid nephropathy", leading to renal fibrosis and upper urinary tract cancer. Traditional Moroccan medicine still often uses Aristolochia species under the vernacular name of Bereztem for the treatment of numerous ailments, notably cancer, diabetes or digestive tract disorders. As the botanical identity and renal toxicity of used species remain unexplored, the safety of patients may be threatened.