Résumé : Brachytherapy was employed as curative treatment modality for localized prostate cancer early in the 20th century. Transperineal implantation of prostatic radioactive seeds is generally safe, however serious complications may occur. Although the half –life of the I125 is about 60 days, literature review showed that Solitary Rectal Ulcer tends to occur months to years after the initial treatment. We present a case of 72 year-old man, who complained of “seeds” anal discharge 7 years after prostate brachytherapy. Paraclinical investigations showed Solitary Ulcer of the Rectum with extra urethral prostatic-rectal fistula. Laparoscopic Loop colostomy was performed. The 4 months follow-up period was uneventful, and the symptoms had resolved. Currently the patient is awaiting colostomy reversal.