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Study of parameters important in the spheronisation process

par Baert, Lieven;Vermeersch, Hans;Remon, Jean Paul;Smeyers-Verbeke, Johanna;Massart, Désiré Luc
Référence International journal of pharmaceutics, 96, 1-3, page (225-229)
Publication Publié, 1993-07

Article révisé par les pairs

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Résumé :

An experimental design was used to determine the influence of parameters that are important in the extrusion-spheronisation process. The parameters tested were water content of binary mixtures of Avicel PH 101®/water, spheroniser speed and spheronisation time. They appeared to have a significant influence on the quality of the spheres. By using a Pareto analysis, optimal parameter settings for water content, spheroniser speed and spheronising time were obtained. © 1993.