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HLA antigens and schizophrenia: A pool of two studies

par Gattaz, Wagner Farid;Beckmann, Helmut;Mendlewicz, Julien
Référence Psychiatry research, 5, 2, page (123-128)
Publication Publié, 1981

Article révisé par les pairs

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Résumé :

Results from two studies on HLA antigens in schizophrenic patients were pooled and analyzed. A statistically significant difference appeared in the frequency for HLA-B27, which was increased in the patient group (n = 164) as compared to the controls (n = 585). The strong correlation between this antigen and some forms of arthropathies and the fact that arthrophaties and schizophrenia very seldom occur in the same individual suggest that HLA-B27 could serve as a genetic marker for both diseases. The development of either one or the other may depend upon the interplay between the genetic marker (HLA-B27) and other biological and environmental factors. In addition to the potential value of HLA-B27 as a marker for vulnerability to schizophrenia, the human leucocyte antigens may also serve to differentiate between various subtypes of the illness. © 1981.