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Réduction de l'incidence de séroconversion envers l'herpésvirus bovin 1 en cheptels mixtes laitier/viandeux par l'administration répétée de vaccins marqués inactivés

par Dispas, Marc;Vanopdenbosch, Emmanuel;Kerkhofs, Pierre;Kerkhofs, Pierre ;Lemaire, Myléne;Speybroek, N.;Berkvens, Dirk;Dramaix Wilmet, Michèle ;Dupont, Alain;Boelaert, Frank;Thiry, Eric
Référence Annales de médecine vétérinaire, 153, 2, page (88-104)
Publication Publié, 2009

Article révisé par les pairs

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Résumé :

A cohort study was conducted in dairy/beef mixed herds (DBMH) to assess the efficacy of hyperimmunisation for the control of bovine herpesvirus 1 (IBR). Two protocols using repeated administrations of vaccine were compared to a positive control group (PCG). Only the primovaccination was different in the hyperimmunised herds: in group 1, live attenuated vaccine was given firstly intra-nasally then by intramuscular route, in group 2 an inactivated vaccine was twice given subcutaneously. Boosters were identical in both groups: inactivated vaccines given subcutaneously about every 6 months. In the PCG, yearly vaccination of a part of the animals was the general rule. The efficacy of the protocols was studied by survival analysis considering times to seroconversion towards the gE glycoprotein. In cattle of group 2, a significantly larger proportion of animals remained seronegative compared to group 1 and to PCG. The probabilities of seroconversion were different among groups considering gender and birth cohorts. Although a reduction of gE seroprevalence was observed in group 1, only group 2 showed a significant advantage for the control of IBR in DBMH compared to PCG.