Résumé : Very few studies have been done in sub-Saharan Africa about endoscopic variceal ligation. Objective: We report the experience of digestive endoscopy center of hospital Aristide-Le-Dantec in this procedure. Patients and method: It was a preliminary prospective study from July 2005 to June 2007. All patients having bled from esophageal varices were included. Results: Sixty patients were included during the period of the study. It concerned 17 women and 43 men (sex-ratio at 2.5). The mean age was 34 (extremes: 12 and 69 years). Esophageal varices were at stage 3 in 83.3% and at stage 2 in 16.7% of cases. The eradication of varices was successful in 30 patients (50% of cases). The mean number of sessions required to achieve eradication was 4. The interval time between sessions was of 3.5 weeks. Eight patients were lost of view after a single session of ligation (13%); five others gave up the treatment because of retrosternal pain (N= 3) and intolerance of endoscopy (N= 2). Rebleeding occurred in five patients (8.33%) after 6 to 26 days following the first session of variceal ligation. Two patients died of rebleeding (3.33%). Another patient died of hepatitic encephalopathy after three sessions. Conclusion: This preliminary study about variceal ligation in a digestive endoscopy center in Dakar shows the feasibility and effectiveness of this treatment, as well as its good tolerance in the majority of cases. © 2010 Springer Verlag France.