par Timmermans, Jacques 
;Lievin, Viviane ;Moes, André Jules
Référence S.T.P. Pharma Sciences, 5, 2, page (110-115)
Publication Publié, 1995
;Lievin, Viviane ;Moes, André Jules Référence S.T.P. Pharma Sciences, 5, 2, page (110-115)
Publication Publié, 1995
Article révisé par les pairs
| Résumé : | The weight and/or volume variations of a sample immersed in a fluid medium can be determined with respect to time by means of a resultant-weight measuring apparatus and method. The applicability of this in vitro technique is examined herein for the monitoring of the disintegration process of tablets. Illustrative experiments obtained with different commercially-available tablets indicate that the information provided by the resultant-weight curves faithfully translates the macroscopic changes of the sample and its hydrodynamic evolution in time. Disintegration kinetics can be recorded even for instant release tablets, but the information becomes particularly interesting when the process adopts a sequence with distinct steps, such as with tablets having a composite structure (for example multi-layered modified release tablets, film-coated tablets etc). The magnitude and duration of each step can be measured exactly and it is in turn possible to assess the different parts of the tablet separately and to adjust their formulation or technological characteristics in accordance with the intended hydrodynamic behaviour. |
