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Phenotypic character of phage protein abnormalities induced by bromouracil

par Vansanten, Georgette
Référence Biochemical pharmacology, 14, 3, page (215-216,IN1-IN2,217-222)
Publication Publié, 1965-03

Article révisé par les pairs

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Résumé :

The incorporation of bromouracil, a thymine analogue, into the DNA of bacteriophage T2 stimulates the synthesis of significant quantities of abnormal proteins. Their abnormal character is deduced from the study of certain properties of phages produced in the presence of bromouracil: stability of structure, adsorption on a sensitive bacterial strain and immunologic specificity. The modifications studied are not transmitted to the progeny synthesized in the absence of the base analogue. In the presence of bromouracil, the synthesis of phage DNA and protein is much less affected than the synthesis of virus particles. This difference is attributed to the fact that the abnormal proteins cannot be integrated into the phage particles. © 1965.