par Koulischer, Lucien 
;Fruhling, Janos ;Henry, Jacques
Référence European journal of cancer, 3, 3, page (193-198,IN5-IN8,199-201)
Publication Publié, 1967-08
;Fruhling, Janos ;Henry, Jacques Référence European journal of cancer, 3, 3, page (193-198,IN5-IN8,199-201)
Publication Publié, 1967-08
Article révisé par les pairs
| Résumé : | A cytological study has been made of the chromosomes of bone marrow cells obtained from 9 patients suffering from polycythemia vera and from a patient with essential thrombocythemia. The karyotypes were normal in 7 cases, as found in previous studies of these diseases. In 2 cases, however, there was clinical evidence of leukemic transformation and cytogenetic examination confirmed the diagnosis of chronic myeloid leukemia with Ph1 in the first case, and of acute leukemia with an aneuploid line of 44 chromosomes in the second case. The remaining case exhibited a modal chromosome count of 46 with chromosome lesions resembling those observed after irradiation in 15% of the cells and the Philadelphia chromosome in 10%. Further examination of this last case might enable one to determine the aetiological role of the Philadelphia chromosome in the induction of chronic myeloid leukemia. © 1967. |
