par Ouedraogo, Moustapha 
;Lamien-Sanou, A.;Ramdé, N.;Ouédraogo, Aimé;Ouédraogo, Moussa;Zongo, Salifou P.Salifou;Goumbri, O.;Duez, Pierre ;Guissou, Pierre
Référence Experimental and toxicologic pathology, 65, 3, page (335-339)
Publication Publié, 2013-03
;Lamien-Sanou, A.;Ramdé, N.;Ouédraogo, Aimé;Ouédraogo, Moussa;Zongo, Salifou P.Salifou;Goumbri, O.;Duez, Pierre ;Guissou, PierreRéférence Experimental and toxicologic pathology, 65, 3, page (335-339)
Publication Publié, 2013-03
Article révisé par les pairs
| Résumé : | Oxidative stress due to abnormal production of reactive oxygen species has been implicated in the nephrotoxicity induced by gentamicin. The nephroprotective effect of aqueous-ethanolic extract of Moringa oleifera leaves (150 and 300. mg/kg) was evaluated against gentamicin-induced (80. mg/kg) renal injury in rabbits. Serum urea and creatinine levels were evaluated as the markers of renal nephrotoxicity. At the end of the experiment, the kidneys of rabbits were excised for histological examinations and determination of lipid peroxidation levels. Serum urea and creatinine levels were reduced in the M. oleifera (150 and 300. mg/kg) plus gentamicin treated groups. On histological examinations, kidney of intoxicated rabbits groups which received M. oleifera extract showed reparative tendencies. A highly significant (. p<. 0.01) elevation was observed in lipid peroxidation (LPO) level in the kidneys of gentamicin-intoxicated rabbits whereas combined treatment of M. oleifera and gentamicin group showed a highly significant (. p<. 0.01) depletion in LPO. The present study indicates that aqueous-ethanolic extract of M. oleifera leaves attenuates renal injury in rabbits treated with gentamicin, possibly by inhibiting lipid peroxidation. © 2011 Elsevier GmbH. |
