Résumé : Tobacco mosaic virus labelled with 32P and 14C is infiltrated in the intercellular spaces of leaves where it enters in contact with the parenchyme cells. After 48 hours, an important part of the 32P and 14C of the virus is found incorporated in intracellular organites. The ratio of the amounts of 14C and 32P present in these organites is identical with that of the initially infiltrated virus. On the other hand, the normal proteins and the free amino acids are not labelled by 14C. It seems therefore that the infiltrated virus has penetrated within the cells. However, the infiltrated virus does not multiply. This last fact could be explained by the necessity for virus multiplication of an initial activation, possible only by the contact with the epidermal cells. © 1995.