par Marcelis, Lionel 
;Vanderlinden, W.;Kirsch-De Mesmaeker, Andrée
Editeur scientifique Gasser, Gilles
Référence Inorganic Chemical Biology : principles, techniques and applications, John Wiley and Sons Ltd, U.K., Ed. 1, page (183-213)
Publication Publié, 2014
;Vanderlinden, W.;Kirsch-De Mesmaeker, Andrée Editeur scientifique Gasser, Gilles
Référence Inorganic Chemical Biology : principles, techniques and applications, John Wiley and Sons Ltd, U.K., Ed. 1, page (183-213)
Publication Publié, 2014
Partie d'ouvrage collectif
| Résumé : | This chapter explains why and how some metal complexes are capable of probing DNA-not only its overall structure or topology but also its local properties and characteristics. It strictly focuses on the Ru(II) complexes because for years now they have continued to be studied as DNA photoprobes. The chapter attempts to explain with specific examples why some complexes in particular have been more successful for probing DNA, not only DNA in a test-tube, but also in vivo for cellular biology applications. The chapter begins with a general discussion on the photophysics of Ru(II) complexes. It rationalizes the interactive behaviour of such complexes with different DNA types, from local DNA characteristics to large DNA global structures found in living cells. Specific examples of Ru(II) complexes used for photoprobing special DNA properties will then be discussed. |
