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Breed differences in natriuretic peptides in healthy dogs

par Sjöstrand, K.;Wess, Gerhard;Ljungvall, Ingrid;Häggström, Jens;Merveille, Anne Christine;Wiberg, Maria;Gouni, Vassiliki;Lundgren Willesen, J.;Hanas, Sofia;Lequarré, Anne Sophie;Mejer Sørensen, L.;Wolf, Johanna;Tiret, Laurent;Kierczak, Marcin;Forsberg, S.;McEntee, Kathleen ;Battaille, G.;Seppälä, Eija;Lindblad-Toh, Kerstin;Georges, Michel;Lohi, Hannes;Chetboul, Valérie;Fredholm, Merete;Höglund, Katja
Référence Journal of veterinary internal medicine, 28, 2, page (451-457)
Publication Publié, 2014

Article révisé par les pairs

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Résumé :

Background: Measurement of plasma concentration of natriuretic peptides (NPs) is suggested to be of value in diagnosis of cardiac disease in dogs, but many factors other than cardiac status may influence their concentrations. Dog breed potentially is 1 such factor. Objective: To investigate breed variation in plasma concentrations of pro-atrial natriuretic peptide 31-67 (proANP 31-67) and N-terminal B-type natriuretic peptide (NT-proBNP) in healthy dogs. Animals: 535 healthy, privately owned dogs of 9 breeds were examined at 5 centers as part of the European Union (EU) LUPA project. Methods: Absence of cardiovascular disease or other clinically relevant organ-related or systemic disease was ensured by thorough clinical investigation. Plasma concentrations of proANP 31-67 and NT-proBNP were measured by commercially available ELISA assays. Results: Overall significant breed differences were found in proANP 31-67 (P?