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Impact of Copper-Catalyzed Cross-Coupling Reactions in Natural Product Synthesis: The Emergence of New Retrosynthetic Paradigms

par Evano, Gwilherm ;Theunissen, Cédric ;Pradal, Alexandre
Référence Natural product reports, 30, 12, page (1467-1489)
Publication Publié, 2013

Article révisé par les pairs

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Résumé :

Covering: up to the end of June 2013 Copper-catalyzed Ullmann-Goldberg-type cross-coupling reactions have undergone nothing short of a renaissance over the last decade and an impressive number of procedures are now available for the formation of C-N, C-O and C-S bonds with remarkable efficiencies and surgical precision. These reactions have been recently integrated into natural product synthesis, which clearly resulted in the emergence of new retrosynthetic paradigms and bond disconnections. The impact of copper-catalyzed cross-coupling reactions in natural product synthesis will be overviewed in this article with an emphasis on the evolution of strategies due to copper catalysis, mostly by comparison with alternative tactics and their relative efficiencies. © 2013 The Royal Society of Chemistry.