par Graff, Guy ;Gueuning, Christiane ;Vermeulen, Claudine
Référence Archives internationales de physiologie et de biochimie, 88, 3, page (303-309)
Publication Publié, 1980
Article révisé par les pairs
Résumé : A single systemic injection of 75 μg colchicine/100 g body weight in the lumbar muscles increases within 6 h the permeability of the extensor digitorum longus muscle to inorganic phosphate. Twenty four hours after the injection the specific activities and isotope uptakes of both inorganic and organic-bound acid-soluble phosphates are markedly increased. By the third day a maximal four-fold increase in rate of inorganic phosphate exchange is reached. The observed effects are slowly reversible, a near normal situation obtaining after 30 days. They are qualitatively different from those observed after administration of vincristine sulphate and bupivacaine (Marcaine).