par Wautrecht, Jean-Claude 
Référence Revue médicale de Bruxelles, 18, 3, page (103-106)
Publication Publié, 1997-06
Référence Revue médicale de Bruxelles, 18, 3, page (103-106)
Publication Publié, 1997-06
Article révisé par les pairs
| Résumé : | Hyperhomocysteinemia is an independent risk factor for atherosclerosis and cardiovascular disease. The cause of hyperhomocysteinemia is either an inborn metabolic defect or acquired. Main causes are either a defective homocysteine remethylation (thermolability of the enzyme 5,10-methylenetetrahydrofolate reductase) or nutritional deficiencies of B vitamins especially folic acid. The relative risk for myocardial infarction has been found of 3,1 in case of hyperhomocysteinemia. It is considered that a 5 μM/l homocysteine increment elevates vascular risk by as much as cholesterol increases of 20 mg/dl. B vitamins supplements are potentially useful. |
