par Moreno Reyes, Mario Rodrigo 
;Kerkhofs, Myriam ;L'Hermite-Balériaux, Mireille ;Thorner, Michael O.;Van Cauter, Eve ;Copinschi, Georges
Référence American journal of physiology: endocrinology and metabolism, 274, 5 37-5, page (E779-E784)
Publication Publié, 1998-05
;Kerkhofs, Myriam ;L'Hermite-Balériaux, Mireille ;Thorner, Michael O.;Van Cauter, Eve ;Copinschi, Georges Référence American journal of physiology: endocrinology and metabolism, 274, 5 37-5, page (E779-E784)
Publication Publié, 1998-05
Article révisé par les pairs
| Résumé : | A complex interrelationship exists between sleep and somatotropic activity. In humans, intravenous injections of growth hormone-releasing hormone (GHRH) given during sleep consistently stimulate slow-wave (SW) sleep, particularly when given in the latter part of the night. In the present study, the possible somnogenic effects induced under similar conditions by GH-releasing peptide (GHRP) were investigated in seven young healthy men. Bolus intravenous injections of GHRP-2 (1 μg/kg body wt) or saline, in randomized order, were given after 60 s of the third rapid-eye- movement period. All GHRP injections were immediately followed by transient prolactin elevations and by GH pulses of a magnitude within or around the upper limit of the physiological range. Except for a nonsignificant tendency to increased amounts of wakefulness during the 1st h after the injection, no effects of GHRP-2 administration on sleep were detected. There was in particular no enhancement of SW sleep. Thus, in contrast to GHRH, late-night single injections of GHRP-2 at a dosage resulting in similar GH elevations have no stimulatory effects on SW sleep. The present data provide evidence against the involvement of the GHRP axis in human SW sleep regulation. |
