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Monitoring a hypothetical channelopathy in Chronic Fatigue Syndrome: Preliminary observations

par Nijs, Jo;Demanet, Christian;McGregor, Neil;De Becker, Pascale;Verhas, Michel ;Englebienne, Patrick;De Meirleir, Kenny
Référence Journal of chronic fatigue syndrome, 11, 1, page (117-133)
Publication Publié, 2003

Article révisé par les pairs

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Résumé :

This study was aimed at monitoring of a previously suggested channelopathy in Chronic Fatigue Syndrome, and at searching for possible explanations by means of immune system characteristics. Twenty-seven CFS patients and 20 age and sex matched healthy volunteers were recruited. RNase L-ratio, percent of the norm of whole body potassium content, serum electrolytes (sodium, calcium and potassium), immune cells, blood cell count and erythrocyte sedimentation rate were determined. More than fifty percent of our patients presented with abnormal whole body potassium content. Eight patients had increased, while six had depleted potassium content. Discriminant function analysis revealed that the CFS patients and control subjects could be differentiated on immunophenotyping with the predominant cell differences being the increase in CD19+ CD5+ (mature B-) cells and the decrease in CD3-CD16+ CD56+ (NK) cells in both the percentage and count distributions. The fall in NK-cells was very strongly associated with increases in the RNase L-ratio and falls in serum calcium levels. In addition, four patients with low serum calcium levels showed lower whole body potassium levels. In conclusion, these observations suggest a channelopathy in a subset of CFS patients, probably induced by the deregulated 2-5A RNase L antiviral pathway. Ζ 2003 by The Haworth Press, Inc. All rights reserved.