par Kirsch-Volders, Micheline 
;Hens, Luc;Susanne, Charles
Référence Human genetics, 54, 1, page (69-77)
Publication Publié, 1980
;Hens, Luc;Susanne, Charles Référence Human genetics, 54, 1, page (69-77)
Publication Publié, 1980
Article révisé par les pairs
| Résumé : | 'Generalized distances' between centromeres and between telomeres were statistically analyzed (x2 tests) in 100 trypsin-banded metaphase figures derived from normal males. Analysis of association tendencies on the first column of obtained c-c, p-p, q-p, and p-q histograms showed significant heterochromatic attraction not only between nonacrocentrics and acrocentrics but also between 2 nonacrocentric chromosome pairs (1 and 16). However, since not all c-heterochromatin-rich chromosomes were involved in associations (pair 5), and conversely, since chromosomes without an important centrometric heterochromatin block were involved in associations (pairs 8 and 11), it is probable that centromeric heterochromatin is not the only factor responsible for chromosome association. Moreover associations occur not only at the centromeres; in the circle analysis of the binding capacity of the telomeres or centromere of one chromosome pair with the telomeres or the centromeres of all other chromosome pairs, the authors also found preferential associations for T(4,13), T(9,15), T(11,15), T(13,19), T(15,19), T(17,18), T(17,22), and T(19,20). They therefore suggest that heterochromatin is not the only reason for chromosome association and that telomeres may also play an important part in this process. |
