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Corticotropins (ACTH). XII. Acid-base equilibria of α-corticotropin and bovine corticotropin

par Leonis, José ;Ll, Choh Hao
Référence Journal of the American Chemical Society, 81, 2, page (415-419)
Publication Publié, 1959

Article révisé par les pairs

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Résumé :

Titration curves for α-corticotropin and bovine corticotropin liave been obtained in 0.1 M KC1 solutions at 24.5°. The degree of ionization of phenolic groups has also been determined spectrophometrically. From these data, intrinsic ionization constants (pK i) of all acidic and basic groups in the corticotropins, as well as values for the electrostatic parameter (w), have been estimated. The relationship of the amino acid sequence in the corticotropin molecule to the estimated values for pK i and w is discussed.