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Hole of plasma free fatty acids in the control of insulin secretion in man

par Balasse, Edmond ;Ooms, Henri
Référence Diabetologia, 9, 2, page (145-151)
Publication Publié, 1973-04

Article révisé par les pairs

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Résumé :

The aim of the present work was to study the effects of experimental changes in plasma free fatty acid (FFA) levels on basal insulin (IRI) concentration and on β cell response to IV glucose, tolbutamide or glucagon in man. Each of the 53 subjects tested was studied on two separate occasions: i) in the basal state; ii) after an experimental decrease or increase in plasma FFA levels induced, respectively, by administration of nicotinic acid or the combination of a fat meal and heparin. The lowering of plasma FFA resulted in a small but significant fall in basal insulin concentration and in a 30% decrease in. IRI response whatever the insulinotropic agent used. On the other hand, experimental elevation of plasma FFA enhanced pancreatic response to glucose (+178%) and tolbutamide (+58%), but did not alter significantly the IRI response to glucagon. Both the increase and the decrease in FFA concentration resulted in a reduction in the rate of glucose assimilation. - These results provide arguments for a role of plasma FFA in the control of insulin secretion and of insulin sensitivity in man. © 1973 Springer-Verlag.