Levamisole and human lymphocyte surface markers

Wybran, Joseph; Govaerts, André

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Levamisole and human lymphocyte surface markers

par Wybran, Joseph

;Govaerts, André

Référence Clinical and experimental immunology, 27, 2, page (319-321)
Publication Publié, 1977

Article révisé par les pairs

Résumé :

The action of various concentrations of levamisole on normal human lymphocytes was investigated in vitro. The action of levamisole (10-1 mg to 10-8 mg%) upon rosette formation was studied using 2 rosette assays with SRBC (the active and the total T rosette tests) to quantify T cells and the EAC assay to quantify B cells. Levamisole at only 10-3 mg% significantly increased the percentage of both active and total T cells. In sharp contrast, levamisole between 10-2 and 10-7 mg% significantly decreased the EAC percentage. It is concluded that levamisole promotes a better expressivity of T cell receptor and decreases the expressivity of C3 receptor.

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