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Detection of motor and non-motor symptoms of end-of dose wearing-off in Parkinson's disease using a dedicated questionnaire: A Belgian multicenter survey

par Santens, Patrick;de Noordhout, Alain Maertens;Cras, Patrick;Dethy, Sophie ;Flamez, Anja;Gonce, Michel;Jeanjean, Anne;Pickut, Barbara;Supiot, Frédéric ;Vandenberghe, Wim;Vanderheyden, Jean-Emile;Van Der Linden, Chris;Van Zandijcke, Michel
Référence Acta neurologica belgica, 106, 3, page (137-141)
Publication Publié, 2006-09

Article révisé par les pairs

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Résumé :

In this report the usefulness of a dedicated questionnaire to detect end-of-dose wearing-off (EODWO) fluctuations in PD was studied. One hundred and sixty patients were administered an 18-item questionnaire encompassing both motor and non-motor phenomena. One hundred and eight (86%) reported EODWO, defined as the occurrence of at least one symptom improving by drug intake. Motor phenomena were significantly more frequent and non-motor phenomena never occurred in isolation. This questionnaire was deemed useful by most participants.