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Animal model for cholesteatoma induced in the gerbil: will the profiles of differentiation/growth-regulatory markers be similar to the clinical situation?

par Choufani, Georges ;Roper, Nicolas ;Delbrouck, Carine ;Hassid, Sergio ;Gabius, Hans-Joachim
Référence The Laryngoscope, 117, 4, page (706-711)
Publication Publié, 2007-04

Article révisé par les pairs

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Résumé :

Cholesteatoma is a benign tumor of the middle ear characterized by an aggressive and invasive potential. The only current treatment being surgery, it is important to have access to a reliable animal model to study and better understand cholesteatoma pathogenesis. Our study aimed to examine the biological validity of the most common experimental model of cholesteatoma: the Mongolian gerbil.