par Couturier, Etienne 
;Malaisse, Willy
Référence British Journal of Pharmacology, 71, 1, page (315-320)
Publication Publié, 1980
;Malaisse, Willy Référence British Journal of Pharmacology, 71, 1, page (315-320)
Publication Publié, 1980
Article révisé par les pairs
| Résumé : | Hypoglycaemic sulphonylureas, such as tolbutamide and gliclazide, provoke the translocation of calcium from an aqueous medium into or across a hydrophobic region. The combined effect of sulphonylureas and antibiotic ionophores upon such a process was investigated. The magnitude of the sulphonylurea‐induced translocation of calcium was more marked in the presence than in the absence of A23187. Gliclazide and tolbutamide also enhanced, although less markedly, X537A‐mediated calcium translocation. The effect of the sulphonylureas was even less marked in the presence of both ionophores, which acted synergistically in causing calcium translocation. A non‐hypoglycaemic sulphonylurea and diazoxide failed to affect ionophore‐mediated calcium translocation. Gliclazide failed to enhance X537A‐mediated sodium translocation. It is proposed that the primary site of action of hypoglycaemic sulphonylureas upon calcium‐dependent physiological processes may correspond to a drug‐induced facilitation of calcium transport across the plasma membrane, as mediated by native ionophores. 1980 British Pharmacological Society |
