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Dynamics of insulin release and microtubular-microfilamentous system: IV. Effect of colchicine upon sulphonylurea-induced insulin secretion

par Van Obbergen, Emmanuel ;Devis, Ghislain;Somers, Guido;Ravazzola, Mariella;Malaisse Lagae, Francine ;Malaisse, Willy
Référence European journal of clinical investigation, 4, 5, page (307-312)
Publication Publié, 1974-10

Article révisé par les pairs

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Résumé :

Colchicine failed to inhibit and actually enhanced insulin release evoked by gliclazide at a low glucose concentration (0.3 mg/ml). The facilitating action of colchicine was invariably present, whatever the concentration of (2x10- 5 to 10- 3 M) and length of exposure to (25 to 120 min) the mitotic spindle inhibitor. Colchicine, and similarly cytochalasin B, also minimized the reduction in insulin output otherwise observed during the second of 2 successive stimulations with sulphonylurea. These data suggest that the short lived secretory response evoked by sulphonylurea corresponds to a modality of insulin release which does not require the oriented intracellular transport of secretory granules.